Total Synthesis of Chrysosporazine D: Combating Multidrug Resistance in Cancer Cells

Voiceover

Presenter(s)

Alexander Cocolas

Abstract or Description

Chrysosporazines are a family of newly isolated natural products that have demonstrated an ability to reverse chemotherapeutic resistance in cancer cell lines. To date, the chrysosporazines are only produced by the Chrysosporium sp. fungus found within an Australian Mugil mullet fish’s gastrointestinal tract, thus limiting future studies. Herein, we propose the first total synthetic route towards chrysosporazine D following a convergent strategy using a palladium-catalyzed cyclization to generate the piperazine core motif. This protocol is flexible, allowing for chrysosporazine E to also be isolated with slight modification.

Mentor

Thomas D. Montgomery